The reason I particularly want to run Desire is that Boros Deck Wins is most likely the best deck again in the PTQ season, and Familiar is just asking to eat a Helix a lot. With Desire in the current (standard) configuration, I can't possibly win unless I won before the Big Turn happens - BUT, if you're looking to win small around Sunscape Familiar then I forsee some problems.
If you're competent enough, you're going to win with or without Mind's Desire. The control matchup's that good.
Where is the claim that Boros Deck Wins is tops comming from? I'm not being antogonistic, but online it would appear that the UW and UR TRON decks are completely dominating the format. Has Boros been doing well in the premier events lately, or is this claim being made based on intuition?