Look bub, you need some help first of all the serum powder in main is something I've seen like 2 people do because you have to remove kill conditions if you f it up. Reverent Silence main board would surprise the crap out of anyone, but it's wasted slots. I like Oxidize personally, that's all I have to say about that. Contagion and Emerald Charm big no's. Chain yes, all the way. And try sideboarding in City of Brass, to handle the color issues.
Serum Powder is better in the main than Careful Study. Reliably having Bazaar is better than relying on Careful Study and Bazaar is immune to the likes of Duress, Thoughtseize and Force of Will which are all common in main decks.
Powder decks have outperformed decks running Careful Study and Breakthrough.
For the board, I prefer rainbow lands because I want access to Chain of Vapor, hardcast Therapy and Emerald Charm. You can try a mix of fetches and duals, but you end up dredging the land you want too often.
I consider Darkblast to be better than Contagion because it functions as a dredger and you can reliably find it in time for a tutored up Yixlid Jailer. Also, being able to reliably remove Welder is huge in many matchups since it is the second Crypt activation that beats you rather than the first.
