A lot of people usually love to say at this point “That's why I love Tanglewire with Smokestack! It's a combo!� Well, they are both individually powerful cards, but they are not a combo. Essentially, they both put their disruptive abilities on the stack. However, whichever one is the most potent is going to be the only one that your opponent notices on their turn. If you have more tokens on Tanglewire, your opponent won't be any further disrupted by it – they can just sacrifice their tapped permanents.
oh my god that was funny.