Nick, I think Mishra's (the card itself) is even better now with the opportunity to play Thirst for Knowledges. Blue shops is not only possible but it was at one time pretty good
The concept behind the deck was borderline playable. There were some cute cards (the 4/3 flyer whose name escapes me comes to mind), but the underlying issue was that you were forced to play lands that produced colored mana.
Splashing blue leaves me with a weaker mana base, as those blue-producing lands will come at the cost of cards like Ancient Tomb. Playing something like Thirst for Knowledge also dis-incentivizes playing Spheres, which is really dangerous right now.
Consider this; is Thirst for Knowledge better in a blue deck with counter-magic, draw spells, etc., or is it better in a Shop deck? Many of the strategies that the Shop deck wants to put to work nerf Thirst for Knowledge.
I've actually played Thirst for Knowledge in Shops before (though I had Gilded Lotus in my deck back then). It's an ancient reference, but it's one that can be called on. If you were going to play a Thirst for Knowledge Shop deck, you'd need to be light on Spheres and you'd want to make use of Welder (to turn Thirst's pitch aspect into an asset). At the very least, you'd likely want to be U/R.
That leaves you with an awkward mana base, a fragile creature you need to lean on (that's hit by Misstep (and it's not like you can just throw Caverns in this deck, like we did with MUD Marinara)), and a draw engine which you may not really need, and makes your Spheres counteractive.
I'm all for trying new things, and Lord knows I've been wrong many times before, but I don't like the idea of Thirst in Shop decks. I'm exceptionally pessimistic on Shops right now, and if I had to play in a tournament, I wouldn't run them.
