Quote Tainted Mask is an Aggro/combo and a lot more aggro than combo so the only way it's gonna give you good results is by playing it as an aggro deck.
Tainted Mask is aggro (That's why I put the "combo" in quotes). In any case, to play it you have to get a threat out quick, either Mask-Nought or Negator, and you have to have the disruption too. Most of the time, you'll be wanting to go Mask-Nought, and that is why so much of the deck is devoted to getting them out quickly.
Quote I'm sure you can find an answer to artifacts in blue, shaman is not so good in the deck or at least doesn't deserve to split red for.
Let's see... Hurkyl's Recall (also 1 cc, and doesn't get rid of the Chalice permanently) and Energy Flux (not even worth running). Recoil could be an option, but it really seems like it's a bit slow.
Red, on the other hand, offers Gorilla Shaman (permanent solution), Overload, Rack and Ruin (not a great choice in some cases), Meltdown, etc... Now we know that Keeper deck armed with Chalice will cause problems for this deck, let alone other decks packing Chalice that can get 4 mana quickly enough (wMUD, Chalice Black), so red seems like a logical choice to make a countermeasure if you really want to play Tainted Mask.